Everything about Histocompatibility totally explained
Histocompatibility is the property of having the same, or mostly the same,
alleles of a set of
genes called the
major histocompatibility complex. These genes are expressed in most tissues as
antigens, to which the
immune system makes
antibodies. The immune system at first makes antibodies to all sorts of antigens, including those it has never been exposed to, but stops making them to antigens present in the body. If the body is exposed to foreign antigens, as by getting a tissue
graft, it attacks the foreign material unless it's histocompatible.
A similar system exists in many
plants; its purpose isn't to reject grafts, but to prevent
inbreeding. Pollen from a plant sharing a histocompatibility gene with the female either fails to grow or dies soon after germinating.
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